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DL-Pyroglutamic acid

CAS No. 149-87-1

DL-Pyroglutamic acid( —— )

Catalog No. M28638 CAS No. 149-87-1

DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DL-Pyroglutamic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen.?
  • Description
    DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen.?
  • In Vitro
    DL-Pyroglutamic acid results 50 and 100% inactivation of the antigen of 0.01-0.025% and 0.025-0.05%, respectively.DL-Pyroglutamic acid is a possible glutamate antagonist, blocks glutamate miniature-end-plate potential in locust muscle-Druce and Bradford.
  • In Vivo
    DL-Pyroglutamic acid (0.775 mM/L) completely abolishes the myoclonic jerks and EEG spikes in rats model of epileptic by cobalt implantation in the sensorimotor cerebral cortex.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Pyroptosis|Caspase-1|IL-1β|inflammation
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    149-87-1
  • Formula Weight
    129.114
  • Molecular Formula
    C5H7NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (774.53 mM)
  • SMILES
    O=C(O)C(CC1)NC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rabuffetti, M., Sciorati, C., Tarozzo, G., et al. Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. Journal of Neuroscience 20, 4398-4404 (2000).
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